Inspire Therapy Approved for Sleep Apnea Patients at Military and VA Hospitals

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Inspire device for sleep apnea is now included in U.S. Government Services Administration’s Federal
Supply Schedule

Minneapolis, MN – April 22, 2015 – Inspire Medical Systems, Inc., announced today that Inspire® Upper
Airway Stimulation (UAS) therapy has been approved for inclusion in the Government Services
Administration (GSA) Federal Supply Schedule (FSS). The agreement enables access to Inspire therapy to
patients cared for at Veteran Administration hospitals, military treatment facilities, and Indian Health
Services hospitals. Inspire therapy is an FDA approved implantable device for the treatment of
Obstructive Sleep Apnea (OSA), a common condition affecting 18 million Americans.

According to the U.S. Department of Veterans Affairs (VA), one out of every five war veterans has been
diagnosed with OSA—compared with only five out of 100 civilians in the general population. Between
2008 and 2010, the number of veterans who received medical benefits related to sleep apnea grew by
61 percent, from 39,145 cases in 2008 to 63,118 cases in 2010. Depending on the degree of severity,
OSA can be a potentially life-threatening condition. Recent research shows that a person with poorly
managed sleep apnea is at increased risk for heart attack, stroke, weight gain, high blood pressure and
heart failure.

“With this approval, military personnel and veterans with sleep apnea who are unable to use
Continuous Positive Airway Pressure will now have access to Inspire therapy and hopefully a better
night’s sleep,” said Tim Herbert, CEO of Inspire Medical Systems. “We are very proud of this
achievement and happy that many veterans and military personal will be able to benefit from Inspire
therapy.”

While Continuous Positive Airway Pressure (CPAP) is often successful, studies show that roughly half of
all patients that start CPAP eventually become non-compliant. In contrast to CPAP, Inspire therapy
works inside the body and with a patient’s natural breathing process. The implantable system includes a
small generator, a sensing lead and a stimulation lead. Turned on by a handheld remote, it delivers mild
stimulation to key airway muscles, which keeps the airway open during sleep. Inspire therapy is
approved to treat a subset of people with moderate to severe OSA who are unable to use CPAP therapy.

The Tampa VA is the first VA hospital to offer Inspire therapy. Several more VA and military hospitals are
expected to complete training and offer Inspire therapy in the second half of 2015. Military veterans and
personnel can learn more and view hospitals offering Inspire therapy by visiting www.inspiresleep.com.

About Inspire therapy
Inspire® Upper Airway Stimulation (UAS) is an FDA approved treatment for people with moderate to
severe OSA who are unable to use CPAP. The single external component, a handheld Inspire sleep
remote, is used to turn the therapy on before bed and off upon waking. When activated, Inspire therapy
senses breathing patterns and delivers mild stimulation to key airway muscles, which keeps the airway
open during sleep. Patients implanted with Inspire therapy who participated in the STAR (Stimulation
Therapy for Apnea Reduction) pivotal clinical trial experienced a 68 percent reduction in apnea events, a
70 percent reduction in oxygen desaturation events, and significant improvements in Quality of Life.
These results were published in the January 9, 2014, issue of the New England Journal of Medicine. For
more information, visit: http://www.multivu.com/mnr/7169651-fda-approves-inspire-upper-airway-
stimulation-therapy-sleep-apnea

About Inspire Medical Systems
Inspire Medical Systems, based in Minneapolis, Minn., was formed in 2007 when the technology and a
significant intellectual property portfolio was spun-out of Medtronic (NYSE: MDT). Inspire Medical
Systems has developed the FDA approved Inspire system for the treatment of Obstructive Sleep Apnea
(OSA). Privately held, investors include Aperture Venture Partners, GDN Holdings, Johnson & Johnson,
Kleiner Perkins Caufield & Byers, Medtronic, OrbiMed Advisors, Synergy Life Science Partners, TGap
Ventures and US Venture Partners.

To learn more and to locate medical centers offering Inspire therapy, visit Inspire Medical Systems on
the web at www.inspiresleep.com.

Media contacts:
Helen Shik or Rachel Gross
MSLGROUP Boston
781-684-0770
InspireMedical@mslgroup.com