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Inspire Medical Systems, Inc. Announces Two Additional Coverage Policies from Blue Cross Blue Shield Healthcare Plans

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MINNEAPOLIS, Minnesota – August 17, 2020 – Inspire Medical Systems, Inc. (NYSE: INSP) (“Inspire”), a medical
technology company focused on the development and commercialization of innovative and minimally invasive
solutions for patients with obstructive sleep apnea (“OSA”), announced today that two additional Blue Cross Blue
Shield (“BCBS”) plans will provide coverage for the Company’s Inspire therapy.

Florida Blue, part of the Blue Cross and Blue Shield (“BCBS”) Association, is the leading health insurer in Florida
and covers approximately 5.9 million members, and issued their policy with an effective date of August 15, 2020.
Blue Cross and Blue Shield of Minnesota (“BCBS Minnesota”), the largest health plan in Minnesota, is an
independent licensee of the BCBS Association and covers 2.7 million lives. The effective date of the policy is
October 5, 2020.

“We are pleased to receive these positive coverage decisions from two more BCBS Plans, bringing the total to 31
BCBS plans covering Inspire therapy. As health plans continue to update their coverage policies to include Inspire
therapy, an increasing number of patients and physicians will have access to our innovative therapy,” said Tim
Herbert, President and Chief Executive Officer of Inspire Medical Systems. “With the addition of Florida Blue and
BCBS Minnesota, we now have 58 coverage policies, representing over 190 million lives, that cover Inspire
therapy.”

In addition to the 58 commercial coverage policies, Inspire therapy also has Medicare coverage across the entire
United States.

About Inspire Medical Systems

Inspire is a medical technology company focused on the development and commercialization of innovative and
minimally invasive solutions for patients with obstructive sleep apnea. Inspire’s proprietary Inspire therapy is the first
and only FDA-approved neurostimulation technology that provides a safe and effective treatment for moderate to
severe obstructive sleep apnea.

For additional information about Inspire, please visit www.inspiresleep.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation
Reform Act of 1995. All statements other than statements of historical facts are forward-looking statements,
including, without limitation, statements regarding further updates to health plans’ coverage policies to include
Inspire therapy and patients’ and physicians’ increased access to Inspire therapy. In some cases, you can identify
forward-looking statements by terms such as ‘‘may,’’ ‘‘will,’’ ‘‘should,’’ ‘‘expect,’’ ‘‘plan,’’ ‘‘anticipate,’’ ‘‘could,’’
“future,” “outlook,” “guidance,” ‘‘intend,’’ ‘‘target,’’ ‘‘project,’’ ‘‘contemplate,’’ ‘‘believe,’’ ‘‘estimate,’’ ‘‘predict,’’
‘‘potential,’’ ‘‘continue,’’ or the negative of these terms or other similar expressions, although not all forward-looking
statements contain these words.

These forward-looking statements are based on management’s current expectations and involve known and
unknown risks and uncertainties that may cause our actual results, performance or achievements to be materially
different from any future results, performance or achievements expressed or implied by the forward-looking
statements. Such risks and uncertainties include, among others, estimates regarding the annual total addressable
market for our Inspire therapy in the U.S. and our market opportunity outside the U.S.; future results of operations,
financial position, research and development costs, capital requirements and our needs for additional financing;
commercial success and market acceptance of our Inspire therapy; the impact of the ongoing and global COVID-19
pandemic; and general and international economic, political, and other risks, including currency and stock market
fluctuations and the uncertain economic environment. Other important factors that could cause actual results,
performance or achievements to differ materially from those contemplated in this press release can be found under
the captions “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of
Operations“ in our Annual Report on Form 10-K for the fiscal year ended December 31, 2019, as updated in our
Quarterly Report on Form 10-Q for the quarter ended June 30, 2020, and as such factors may be updated from time
to time in our other filings with the SEC, which are accessible on the SEC’s website at www.sec.gov and the
Investors page of our website at www.inspiresleep.com. These and other important factors could cause actual
results to differ materially from those indicated by the forward-looking statements made in this press release. Any
such forward-looking statements represent management’s estimates as of the date of this press release. While we
may elect to update such forward-looking statements at some point in the future, unless required by applicable law,
we disclaim any obligation to do so, even if subsequent events cause our views to change. Thus, one should not
assume that our silence over time means that actual events are bearing out as expressed or implied in such
forward-looking statements. These forward-looking statements should not be relied upon as representing our views
as of any date subsequent to the date of this press release.

Investor & Media Contact:
Bob Yedid
LifeSci Advisors
646-597-6989
[email protected]