Inspire Medical Systems, Inc. Announces First BCBS Coverage Policy following Evidence Street’s Positive Therapy Indication Summary

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MINNEAPOLIS, MN – January 14, 2019 – Inspire Medical Systems, Inc. (NYSE: INSP) (“Inspire”), a
medical technology company focused on the development and commercialization of innovative and
minimally invasive solutions for patients with obstructive sleep apnea (“OSA”), announced today that
Blue Cross of Idaho has issued a positive coverage policy of Inspire therapy. This is the first coverage
policy issued following BCBS Evidence Street’s January 7, 2019 report, which stated there is sufficient
evidence to determine that Inspire therapy results in a meaningful improvement in net health outcomes for
patients meeting specified criteria.

Blue Cross of Idaho, the state of Idaho’s leading health insurer, is a not-for-profit mutual insurance
company covering approximately 500,000 members. Blue Cross of Idaho is an independent licensee of
the Blue Cross and Blue Shield Association (BCBSA). The Blue Cross of Idaho policy is effective March
20, 2019. This policy has a few changes from the Evidence Street summary including a BMI of less than
32. This Blue Cross of Idaho is the first policy to include coverage for adolescents who have Down’s
syndrome. It is important to note that this indication is not yet approved by the FDA.
In addition to Blue Cross of Idaho, an additional positive coverage policy became effective January 1,
2019 with Ascension Smart Health. These positive coverage decisions are a result of the large and
growing body of clinical evidence supporting the use of Inspire therapy for the treatment of moderate to
severe obstructive sleep apnea.

Ascension Smart Health is the self-funded medical plan offered to associates of select Ascension entities
and their eligible dependents. Ascension is the largest non-profit health system in the U.S. and the world’s
largest Catholic health system and includes approximately 156,000 associates plus 34,000 aligned
providers and over 2,600 sites of care in 22 states and the District of Columbia. The Ascension
SmartHealth policy became effective on January 1, 2019.

“Following the Evidence Street summary this past week, we are very pleased to have the positive
coverage decision from Blue Cross of Idaho in such a short time period. We will continue to work with
physicians and treatment centers to develop additional positive coverage policies with the regional BCBS
systems,” said Tim Herbert, President and Chief Executive Officer of Inspire Medical Systems. “We also
plan to build on our already strong body of clinical data supporting Inspire therapy, and believe this
clinical and real-world data will further result in coverage decisions by other major health plans and
further adoption of Inspire therapy.”

The BCBSA’s Evidence Street platform provides health care decision-makers easy access to impartial
medical evidence reviews for devices, diagnostics and pharmaceuticals and was created to make
BCBSA’s evidence review process of medical technologies and therapies more transparent, efficient and
comprehensive. BCBSA collects and analyzes available peer-reviewed evidence, then synthesizes that
data and ascertains if the evidence is sufficient or insufficient to determine the effect on health outcomes.

About Inspire Medical Systems
Inspire is a medical technology company focused on the development and commercialization of
innovative and minimally invasive solutions for patients with obstructive sleep apnea. Inspire’s
proprietary Inspire therapy is the first and only FDA-approved neurostimulation technology that provides
a safe and effective treatment for moderate to severe obstructive sleep apnea.

For additional information about Inspire, please visit www.inspiresleep.com.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities
Litigation Reform Act of 1995. All statements other than statements of historical facts are forward-
looking statements, including, without limitation, statements regarding the potential impact of BCBS’s
positive assessment, future positive insurance coverage and adoption of Inspire therapy. In some cases,
you can identify forward-looking statements by terms such as ‘‘may,’’ ‘‘will,’’ ‘‘should,’’ ‘‘expect,’’
‘‘plan,’’ ‘‘anticipate,’’ ‘‘could,’’ “future,” “outlook,” ‘‘intend,’’ ‘‘target,’’ ‘‘project,’’ ‘‘contemplate,’’
‘‘believe,’’ ‘‘estimate,’’ ‘‘predict,’’ ‘‘potential,’’ ‘‘continue,’’ or the negative of these terms or other
similar expressions, although not all forward-looking statements contain these words.

These forward-looking statements are based on management’s current expectations and involve known
and unknown risks and uncertainties that may cause our actual results, performance or achievements to be
materially different from any future results, performance or achievements expressed or implied by the
forward-looking statements. Such risks and uncertainties include, among others: estimates regarding the
annual total addressable market for our Inspire therapy in the U.S. and our market opportunity outside the
U.S., future results of operations, financial position, research and development costs, capital requirements
and our needs for additional financing; commercial success and market acceptance of our Inspire therapy;
our ability to achieve and maintain adequate levels of coverage or reimbursement for our Inspire system
or any future products we may seek to commercialize; competitive companies and technologies in our
industry; our ability to expand our indications and develop and commercialize additional products and
enhancements to our Inspire system; our business model and strategic plans for our products, technologies
and business, including our implementation thereof; our ability to accurately forecast customer demand
for our Inspire system and manage our inventory; our ability to expand, manage and maintain our direct
sales and marketing organization, and to market and sell our Inspire system in markets outside of the
U.S.; our ability to increase the number of active medical centers implanting Inspire therapy; our ability to
hire and retain our senior management and other highly qualified personnel; our ability to commercialize
or obtain regulatory approvals for our Inspire therapy and system, or the effect of delays in
commercializing or obtaining regulatory approvals; FDA or other U.S. or foreign regulatory actions
affecting us or the healthcare industry generally, including healthcare reform measures in the U.S. and
international markets; and our ability to establish and maintain intellectual property protection for our
Inspire therapy and system or avoid claims of infringement. Other important factors that could cause
actual results, performance or achievements to differ materially from those contemplated in this press
release can be found under the captions “Risk Factors” and “Management’s Discussion and Analysis of
Financial Condition and Results of Operations“ in our final prospectus filed under Rule 424(b) on
December 7, 2018, as such factors may be updated from time to time in our other filings with the SEC,
which are accessible on the SEC’s website at www.sec.gov. These and other important factors could
cause actual results to differ materially from those indicated by the forward-looking statements made in
this press release. Any such forward-looking statements represent management’s estimates as of the date
of this press release. While we may elect to update such forward-looking statements at some point in the
future, unless required by applicable law, we disclaim any obligation to do so, even if subsequent events
cause our views to change. Thus, one should not assume that our silence over time means that actual
events are bearing out as expressed or implied in such forward-looking statements. These forward-looking
statements should not be relied upon as representing our views as of any date subsequent to the date of
this press release.

Investor and Media Contact:
Bob Yedid
LifeSci Advisors
bob@lifesciadvisors.com
646-597-6989