Inspire Medical Systems, Inc. Announces Draft Local Coverage Determinations Proposing Coverage of Inspire Therapy from Two Regional Medicare Administrators

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Noridian Healthcare Solutions and Palmetto GBA, collectively representing 19 states, issue draft policies
initiating open public comment period

MINNEAPOLIS, MN – August 26, 2019 – Inspire Medical Systems, Inc. (NYSE: INSP) (the “Company or
“Inspire”), a medical technology company focused on the development and commercialization of
innovative and minimally invasive solutions for patients with obstructive sleep apnea, announced today
that two draft Local Coverage Determinations (LCDs) were published proposing coverage of Inspire
therapy.

The proposed draft LCDs are available on the Medicare Coverage Database site for public review. The
Medicare Administrative Contractors (MACs) issuing these first two policies are Noridian and Palmetto,
which collectively represent 19 states. Following the public comment period, which is expected to be 60
days, Noridian and Palmetto will host formal review meetings in September and October, respectively.
Final policies are expected to be issued by Noridian and Palmetto in 2020.

Both draft LCDs from Noridian and Palmetto state that for individuals with obstructive sleep apnea who
are treated with hypoglossal nerve stimulation, the evidence is sufficient to determine that the technology
results in a meaningful improvement in the net health outcomes when utilized as outlined in the LCDs.
The criteria for potential patients identified in the draft policy are closely aligned with the approved U.S.
Food and Drug Administration indication statement for Inspire therapy.

“This is a very positive advancement for the Medicare-aged population that has the potential to streamline
their access to Inspire therapy. The Inspire team has worked closely with the MACs, and specifically
Noridian and Palmetto, to provide the published clinical literature for Inspire therapy, and to respond to
any questions raised during their policy reviews. We look forward to the formal policies from Noridian and
Palmetto, and anticipate that other MACs will also soon issue their draft policies for Inspire therapy,” said
Tim Herbert, President and Chief Executive Officer of Inspire Medical Systems.

Noridian covers Medicare patients in Alaska, Arizona, California, Hawaii, Idaho, Montana, North Dakota,
Oregon, South Dakota, Utah, Washington and Wyoming. Palmetto covers Medicare patients in Alabama,
Georgia, North Carolina, South Carolina, Tennessee, Virginia and West Virginia.

About Inspire Medical Systems

Inspire is a medical technology company focused on the development and commercialization of
innovative and minimally invasive solutions for patients with obstructive sleep apnea. Inspire’s proprietary
Inspire therapy is the first and only FDA-approved neurostimulation technology that provides a safe and
effective treatment for moderate to severe obstructive sleep apnea.

For additional information about Inspire, please visit www.inspiresleep.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities
Litigation Reform Act of 1995. All statements other than statements of historical facts are forward-looking
statements, including, without limitation, statements regarding future local coverage determinations and
additional draft policies for Inspire therapy. In some cases, you can identify forward-looking statements
by terms such as ‘‘may,’’ ‘‘will,’’ ‘‘should,’’ ‘‘expect,’’ ‘‘plan,’’ ‘‘anticipate,’’ ‘‘could,’’ “future,” “outlook,”
‘‘intend,’’ ‘‘target,’’ ‘‘project,’’ ‘‘contemplate,’’ ‘‘believe,’’ ‘‘estimate,’’ ‘‘predict,’’ ‘‘potential,’’ ‘‘continue,’’ or the
negative of these terms or other similar expressions, although not all forward-looking statements contain
these words.

These forward-looking statements are based on management’s current expectations and involve known
and unknown risks and uncertainties that may cause our actual results, performance or achievements to
be materially different from any future results, performance or achievements expressed or implied by the
forward-looking statements. Such risks and uncertainties include, among others, estimates regarding the
annual total addressable market for our Inspire therapy in the U.S. and our market opportunity outside the
U.S.; future results of operations, financial position, research and development costs, capital
requirements and our needs for additional financing; commercial success and market acceptance of our
Inspire therapy; our ability to achieve and maintain adequate levels of coverage or reimbursement for our
Inspire system or any future products we may seek to commercialize; competitive companies and
technologies in our industry; our ability to enhance our Inspire system, expand our indications and
develop and commercialize additional products; our business model and strategic plans for our products,
technologies and business, including our implementation thereof; our ability to accurately forecast
customer demand for our Inspire system and manage our inventory; our dependence on third-party
suppliers, contract manufacturers and shipping carriers; consolidation in the healthcare industry; our
ability to expand, manage and maintain our direct sales and marketing organization, and to market and
sell our Inspire system in markets outside of the U.S.; risks associated with international operations; our
ability to manage our growth; our ability to increase the number of active medical centers implanting
Inspire therapy; our ability to hire and retain our senior management and other highly qualified personnel;
risk of product liability claims; risks related to information technology and cybersecurity; risk of damage to
or interruptions at our facilities; our ability to commercialize or obtain regulatory approvals for our Inspire
therapy and system, or the effect of delays in commercializing or obtaining regulatory approvals; FDA or
other U.S. or foreign regulatory actions affecting us or the healthcare industry generally, including
healthcare reform measures in the U.S. and international markets; the timing or likelihood of regulatory
filings and approvals; risks related to our debt and capital structure; our ability to establish and maintain
intellectual property protection for our Inspire therapy and system or avoid claims of infringement; tax
risks; risks that we may be deemed an investment company under the Investment Company Act of 1940;
regulatory risks; the volatility of the trading price of our common stock; and our expectations about market
trends. Other important factors that could cause actual results, performance or achievements to differ
materially from those contemplated in this presentation can be found under the captions “Risk Factors”
and “Management’s Discussion and Analysis of Financial Condition and Results of Operations“ in our
Annual Report on Form 10-K for the fiscal year ended December 31, 2018, as such factors may be
updated from time to time in our other filings with the SEC, which are accessible on the SEC’s website at
www.sec.gov. These and other important factors could cause actual results to differ materially from those
indicated by the forward-looking statements made in this presentation. Any such forward-looking
statements represent management’s estimates as of the date of this presentation. While we may elect to
update such forward-looking statements at some point in the future, unless required by applicable law, we
disclaim any obligation to do so, even if subsequent events cause our views to change. Thus, one should
not assume that our silence over time means that actual events are bearing out as expressed or implied
in such forward-looking statements. These forward-looking statements should not be relied upon as
representing our views as of any date subsequent to the date of this press release.

Investor and Media Contact:
Bob Yedid
LifeSci Advisors
inspire@lifesciadvisors.com
646-597-6989